The prevalence of hypercalcemia at the time of diagnosis of Addison’s disease is reported to be ∼5.5%–6.0%. 1 As not all cases of adrenal insufficiency present with hypercalcemia, adrenal insufficiency is not easily considered an etiology of hypercalcemia. Although primary hyperparathyroidism and malignancy are the most common causes of hypercalcemia, adrenal insufficiency is a rare but important cause of hypercalcemia. Hypercalcemia is a common disease found in emergency departments and in-patients. Keywords: hypercalcemia, adrenal insufficiency, acute kidney injury This case shows that adrenal insufficiency may manifest as hypercalcemia and acute kidney injury, which implicates that adrenal insufficiency should be considered a cause of hypercalcemia in clinical practice. With the administration of oral hydrocortisone, hypercalcemia was dramatically resolved within 3 days. Basal cortisol and adrenocorticotropic hormone levels and adrenocorticotropic hormone stimulation test confirmed the diagnosis of adrenal insufficiency. Studies for malignancy and hyperparathyroidism showed negative results. Hypercalcemia (11.5 mg/dL) and moderate renal dysfunction (serum creatinine 4.9 mg/dL) were shown in her initial laboratory findings. The patient was admitted to the emergency department with general weakness and poor oral intake. We report a case of secondary adrenal insufficiency presenting as hypercalcemia and acute kidney injury in a 66-year-old female. Mary’s Hospital, Incheon, Republic of KoreaĪbstract: Adrenal insufficiency is an uncommon cause of hypercalcemia and not easily considered as an etiology of adrenal insufficiency in clinical practice, as not all cases of adrenal insufficiency manifest as hypercalcemia. Seung Won Ahn, 1 Tong Yoon Kim, 1 Sangmin Lee, 1 Jeong Yeon Jeong, 1 Hojoon Shim, 1 Yu min Han, 1 Kyu Eun Choi, 1 Seok Joon Shin, 1,2 Hye Eun Yoon, 1,2ġDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, 2Division of Nephrology, Department of Internal medicine, Incheon St.

Adrenal gland kidney